Week 16 of the NFL features crucial divisional matchups, including the Philadelphia Eagles facing the Washington Commanders, where the Eagles aim to clinch the NFC East title. Philadelphia is favored by 3.5 points, with a total points line set at 45.5.

The Eagles have a strong recent record against the Commanders, but the latter has performed well at home against the spread. Other key games include the Cowboys as underdogs against the Buccaneers and the Bengals hosting the Browns.

SportsLine's AI model has been successful in predicting outcomes and offers insights for fantasy football rankings, DFS picks, and betting strategies for this week's games.